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Adrenal insufficiency in patients with decompensated cirrhosis
doi: 10.1172/JCI129192 [DOI] [PMC free article] [PubMed] [Google Scholar] 278
J.EngelkeU
Molecular genetics of brain tumors
The function of NRF2 is twofold: while protecting normal cells from oxidative damage, sustained NRF2 activation in cancer cells promotes survival under stress by upregulating antioxidant genes (e.g., SLC7A11 , HO-1 , GPX4 ), GSH biosynthesis, and regulating iron metabolism to suppress lipid peroxidation and ferroptotic cell death, thereby facilitating tumor progression [22, 23]
