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Adults meeting the studys obesity criteria, who newly initiated tirzepatide or semaglutide, were identified and compared with matched individuals who started naltrexone-bupropion, phentermine, or phentermine-topiramate

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Owing to its high surface area and metabolic activity, trabecular bone is highly sensitive to rapid hormonal and nutritional fluctuations, making it initially more susceptible to CR-induced remodeling alterations

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In mammals, linear growth is regulated by the somatotropic axis, governed by growth hormone (GH) and insulin-like growth factor 1 (IGF-1)