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That's why fitter individuals show smaller increases in HR

About OASIS 4 OASIS 4 was a 64-week phase 3 randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of once-daily oral semaglutide 25 mg versus placebo in 307 adults with obesity (BMI 30 kg/m 2 ) or overweight (BMI 27 kg/m 2 ) with one or more weight-related comorbidities

1 4 The role of GLP-1 RAs in diabetes treatment has evolved over time since their initial US Food and Drug Administration (FDA) approval in 2005

High costs, as well as tolerability issues, remain considerable barriers to a more wide-ranging prescribing of these drugs 1

Chelakkot C, Ghim J, Ryu SH
