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Overall, while the majority of the RCTs demonstrated sound methodological practices, limitations in the reporting of blinding and randomization processes in a few studies should be taken into account when interpreting the overall findings of this scoping review

Specifically, the gut microbiota acts as a metabolic bridge: it ferment dietary nutrients to produce bioactive metabolites (e.g., SCFAs, tryptophan derivatives), which signal to the brain via three pathways: 1

Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds

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