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Additionally, we identified the upregulation of anterior DE and midgut markers, including Insulin-Like Growth Factor Binding Protein 5 ( IGFBP5 ) and S100 Calcium Binding Protein A13 ( S100A13 ) 31

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18 UC is characterized by ulceration of the intestinal mucosal layer in the rectum and colon, which in turn affects the entire colon, resulting in dysregulation of intestinal immune factors and disruption of the structure and function of the intestinal barrier

75 , 76 , 77 The study by Antnez et al

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