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In the CT-like conformation, the bypass motif becomes unstructured, and residues (S21-P28) are not well resolved, suggesting this flexible segment is exposed to the solvent environment

FDA draft guidance on New Approach Methodologies (NAMs): A structural shift in drug development strategy

Fiber terminal positions were mapped onto a standardized mouse brain atlas

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He et al identified an amide derivative of NAC, N-acetylcysteine amide (NACA) in murines as a promising precursor of NAC that increases bioavailability to 67% and increases GSH replenishing capacity by 3-4 fold [68]