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Importantly, this trial compared orforgliprin with oral semaglutide doses that were based on those that are currently available for Rybelsus, but the maximum effective dose offered for the recently approved Wegovy pill for obesity is 25 mg

A significant contributing factor to the prevalence of T2DM is obesity, which is strongly associated with serious consequences such as chronic kidney disease, hypertension, stroke, and liver disease that impair both the quality and quantity of life as life expectancy declines with rising body mass index (BMI) [2]

While tirzepatide shows slightly higher weight loss in studies, semaglutide offers proven results at a lower price point

doi: 10.1111/fcp.12851
Exendin-4 protects against hyperglycemia-induced cardiomyocyte pyroptosis via the AMPK-TXNIP pathway