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Although we used an active-comparator, new-user design, and accounted for a wide range of characteristics, the observational design of our study implies that unmeasured and residual confounding are possible

Jude 2 , J.T

A rapid increase in dose, even following the standard titration schedule, can sometimes lead to an accumulation of effects, resulting in severe discomfort weeks later

The main difference is the amount of medication used
