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and iii) contact with experts to request unpublished data

The imbalance between the production of reactive oxygen species (ROS) and the availability of antioxidants or free radical scavengers can cause oxidative stress, and that further activates an abundance of transcription factors and pro-inflammatory genes such as NF-B, p53, HIF-1, PPAR-, -catenin/Wnt, and Nrf2 [5,6,7]

Paclitaxel was not included in the set of 68 drugs evaluated in the Sharlow et al

Defective antioxidative activity of small dense HDL3 particles in type 2 diabetes: relationship to elevated oxidative stress and hyperglycaemia

23 In contrast to effector T cells, the extent to which regulatory T cells (Tregs) engage PI3K-AKT signaling to promote glucose utilization and the role of glycolysis in Treg biology remain less clear