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According to a 1997 study published in Clinical Endocrinology, leptin resistance can lead to low testosterone levels, which may be linked to low libido as well ( 6 )

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Important safety information: Retatrutide is an investigational medication that hasnt been approved by the MHRA, FDA, or any other regulator as of May 2026

222,224 In addition, it has been shown that NAPRT gene promoter can be hypermethylated resulting in the inhibition of NAPRT epigenetic expression in some types of tumors