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Peer review Peer review information Nature Aging thanks Juan Tena and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Detoxification : One of glutathiones primary roles is detoxification

Additional research is required to explore the potential connections between TM and epigenetic modification

Numerous transporters are found in astrocyte plasmalemma, including those that transport glucose and fatty acids, and astrocytes store energy in the form of lipid droplets 586,598,599 and glycogen 600,601 , which is key in generating L-lactate in the process of aerobic glycolysis 602