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Key signaling pathwaysincluding mTOR, HIF-1, and AMPK regulate these metabolic adaptions, linking cellular energy states with T cell fate decisions

The combination of all three receptor pathways creates metabolic effects greater than the sum of their parts

doi: 10.1076/ceyr.27.5.309.17222

Despite being a less abundant constituent, -humulene demonstrates notable anti-inflammatory and antiproliferative activities in colon, prostate, and breast cancers through inhibition of the NF-B pathway (Ambro et al., 2019)

In line with our murine observations, clusters of inflammatory and SPP1 + macrophages displayed the highest EGFR activity scores (among all immune subsets), also in the re-analyzed human CRC data (Fig