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Additional SSRIs or monoamine oxidase inhibitors (MAOIs) , another class of antidepressants, may increase the possibility of serotonin syndrome, where an excess of serotonin accumulates between brain synapses

doi: 10.1210/jcem.84.11.6153

One of the biggest requirements is something called bioequivalence

Hence, during menopause, these oestrogen receptors cannot do their job properly
