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Current pharmacological data indicates that peptide hormones like semaglutide do not pass efficiently through the mammary gland barrier, similar to insulin and other injectable peptides used safely in breastfeeding populations

Conclusions Across preclinical and translational studies, GLP-1RAs have emerged as promising candidates for NDD therapy, consistently modulating convergent mechanisms of pathology: IR, mitochondrial dysfunction, oxidative stress, proteostasis failure, synaptic loss, and neuroinflammation
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