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To help with this, Eli Lilly worked to have brand-name Zepbound added to the preferred formulary (drug list) of many of the top health insurance companies such as Cigna Healthcare and Express Scripts

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To assess the impact of post-randomization changes in metformin use, two sensitivity analyses were conducted for the CV outcomes: (1) censoring for initiation and discontinuation of metformin during the study using the Cox proportional hazards model described above

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Understanding these mechanisms helps distinguish between expected physiological changes and symptoms requiring medical investigation